Principal Laboratory Research Scientist
Short summary
We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function.
We use the liver as a model organ since it has extraordinary regenerative abilities. We have already identified several interesting genes in metabolic pathways which we hypothesise are important in allowing liver cells to survive better in pathological conditions (Ng.et al, Nature, 2021). We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration. We model these recurrent human somatic driver mutations using patient derived induced pluripotent stem cells (Rouhani et al.
Nature Genetics, 2022), organoids and bio-engineered tissues. We are also developing and applying new technologies in single molecule spatial genomics and in vivo gene editing.
If you are a senior scientist, this may be an excellent opportunity for you to join the lab. You will be heavily involved in the start-up of a major laboratory and will provide senior level support in broad scientific management for the research group.Alongside providing technical assistance to other lab members, there will be opportunities and strong encouragement for you to lead independent projects in areas such in vivo gene editing and liver epigenetics.
Key Responsibilities
As a Principal Laboratory Research Scientist at the Crick, you will be:- Independently devising and leading projects within the TRCE research program
- Establishing new methodologies in the lab
- Maintaining laboratory organisation and supplies
- Supporting the Group Leader in day-to-day operations
- Deputising for when the Group Leader is unavailable
- Training and supporting lab members in standard operating procedures
- Facilitating collaborations within and outside the Crick
About us
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture.We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
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Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status.We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
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