[ref. v77164415] Oxford - Scientist II/III Process Development (Downstream).

Job description:

We want you to feel inspired every day. We’re future-focused and our business is growing. We succeed together through passion, commitment, and teamwork, and so can you.

We are currently recruiting for multiple Scientist roles at different levels within Downstream Process Development. The purpose of these roles is to perform and report laboratory-based experiments or investigations in accordance with scientific or regulatory requirements in line with departmental objectives.

Process Development (PD) is responsible for the development of world-class viral vector manufacturing processes for Oxford Biomedica’s proprietary products and partnered programmes. PD performs a crucial technical role in Oxford Biomedica’s mission to deliver life-changing gene therapies to patients.

Your responsibilities in this role would be:

• Involvement in activities ranging from vector production at laboratory and pilot scales, process development and optimisation, technology transfer, and process characterization activities associated with the manufacture of new gene therapy vectors.
• Design and execute downstream vector purification and vector formulation activities for scale-up/scale-down of existing bioprocesses under the direction of the Team Leader or a senior scientist and in accordance with correct methodologies and procedures.
• Prepare written reports to a high standard and present data within the PD group.
• Liaise with other members of the PD group and assist with other development activities where appropriate.
• Ensure a high standard of record keeping and documentation of experiments and investigations.
• Writing of departmental risk assessments, SOPs, and other documentation where appropriate.

Profile description:

We are looking for:

• Minimum BSc Degree programme level, a postgraduate degree and/or relevant experience
• Sound understanding of downstream purification principles and processes.
• Pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere desirable, but not necessary.
• Experience with the operation of laboratory, pilot or production scale downstream purification processes.
• Competency in data capture, reporting and management systems.
• The capability of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.
• Awareness of regulatory requirements e.g. GMP, GLP, GCP and/or Validation and Quality Management systems.
• Familiarity with data analysis software packages such as Microsoft Excel, JMP, Design Expert™, GraphPad Prism
• Fluency in written and spoken English.

About Us:

We are an innovative leading viral vector specialist focused on delivering life changing therapies to patients. Our innovative solutions and proven expertise allow us and our customers, the biotech and biopharma industry, to deliver life-saving therapies to reach even more patients.

The success of cell and gene therapy products transforms outcomes for millions of people suffering from some of the world’s worst diseases and medical conditions.

We work together, motivated to make a difference, and so can you.

What’s in it for you:

• Highly competitive reward packages
• Wellbeing programmes
• Development opportunities
• A 35-hour working week
• Welcoming, friendly, supportive colleagues
• A diverse and inclusive working environment State of the art laboratory and manufacturing facilities

Collaborate. Contribute. Change lives

We offer:

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.

This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).

Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise.