Computational Chemist (Senior Scientist / Principal Scientist)

Application submission: CV and cover lettervia our website www.omass.com/working-here/

OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, that target solute carriers, complex-bound proteins, and GPCRs.

You will be able to work in state-of-the-art laboratory and modern facilities for optimum collaboration alongside a focused and caring team.

You will already possess expert Computational Chemistry knowledge with experience across all stages of a small-molecule drug discovery from hit ID through to candidate nomination. The role is based in our Oxford site however we are currently working a hybrid model with the option to work from home for part of the week.

To find out more about the meaningful work OMass delivers, as well as our EVP you can find this here https://www.omass.com/

Requirements

• A degree or PhD in chemistry, computational chemistry, cheminformatics or related discipline or equivalent
• Relevant experience in a biotech, pharma or CRO setting
• Expert level experience with a wide range of leading computational tools and approaches including ligand and structure-based techniques, molecular dynamics, free energy perturbation methods and QSAR predictions/model development and deployment
• Expert knowledge with scripting languages (e.g. Python) is required
• Responsible and focused approach to independent and collaborative work, with the ability to prioritise and deliver high quality work to deadlines
• Innovative and ambitious mindset, with an inquisitive and agile approach to problem-solving and overcoming technical challenges; motivated to continuously learn and take on challenges
• Caring and inclusive; respectful and receptive to others’ diverse ideas, experience and perspectives, and enjoys working collaboratively with others as a team
• Excellent communication skills, both written and verbal

• Experience of working across multiple target-types including GPCRs, solute carriers and other membrane proteins
• Familiarity with Schrodinger software suites in addition to a sound knowledge of chemical toolkits is preferred
• Experience of chemical and biological data management systems, such as Dotmatics
• Database administration, curation and interrogation
• Proficient in scientific programming language (e.g. Python, Java, C or C++)
• Experience with machine/deep learning model development and deployment
• An appreciation of relevant scientific disciplines that are related to drug discovery and early development such as target validation, pharmacology, SBDD, LBDD, ADME, structural biology and drug safety/toxicology

• Promote and maintain the highest levels of scientific excellence in computational chemistry, to help deliver OMass’ pipeline objectives
• Developing and implementing tools and processes to interrogate data for the purposes of understanding biological, chemical, pharmacological and ADMET data within the context of a drug discovery program
• Contribute to drug discovery projects by proactively applying computational chemistry techniques to drive programs forward
• Utilize computational methods to design and generate small molecules targeting specific therapeutic goals, prioritizing drug-target affinity and selectivity
• Publish science in high quality journals and publications
• Presenting on OMass’ projects both at internal meetings and externally at conferences
• Fostering collaborations with academia to help ensure that the Computational Chemistry team operates at the highest levels of scientific excellence
• Share information openly and work collaboratively with other departments to help advance different projects and achieve company goals
• Promote and adhere to OMass’ values of being Ambitious, Responsible, Innovative, Focused, Caring and Collaborative

Benefits

OMass offers an excellent benefits package including:

• Private Health Insurance
• Health and wellbeing cashback scheme
• Life Assurance and Income Protection
• Participation in Employee Equity Scheme
• 25 days annual leave, plus bank holidays
• Pension Scheme offering 6% employer contribution
• Learning and Development Opportunities
• Company social events

Any queries relating to the role can be sent to jobs@omass.com.

OMass Therapeutics values diversity and is committed to equality of opportunity, we also have full responsibility to ensure that all employees are eligible to work and live in the UK.